Jacek Skowronski Jacek Skowronski researches immunodeficiency viruses. He studies human immunodeficiency viruses, cognize as HIV, and simian immunodeficiency viruses, bed as SIV. Particularly, he studies the viral protein Nef. This protein plays an important role in the initiation of AIDS. T lymphocytes, the jail cells that be worn-out in AIDS, are cultured to study the affects the viruses have on them. The results showed that Nef dispels the T cell receptor (TCR). It changes the expression of major histocompatibility complex I molecules, known as MHC I, a condition of compatibility between tissues of impertinent objects and the tissues of the soundbox receiving it. This disruption is likely to be involved in the baulk of host immune responses, whether it be human or simian. The haphazardness is characterized as AIDS. To study the function of Nef, he uses contractable molecules to signalize the cells involved in affecting the T lymphocyte.
He as well as studies SIV-infected monkeys to find the importance the Nef and T lymphocyte interactions for AIDS. He tied(p) tries to characterize Nef proteins by isolating them presently from HIV-infected people. Results from his studies will incite in possible drugs that can disrupt the Nef functions and prevent AIDS. If you require to get a full essay, modulate it on our website:
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